This was recommended by a source I trust:
http://www.revouninstaller.com

One of the cool features is it has a crosshair that lets you "shoot" apps and uninstall them, whether they're running, their icon, or even in the system tray.

havent tried it yet, but looks good on paper.

Just posted over at MRU (where I trained on Malware), someone over there is sure to have some sort of opinion on it.

Looks to have potential where uninstall files have got corrupted, but just how reliable it is I couldn't say at this point.

Where possible I'd still use the native uninstall facilities that come with Windows as my first option.

In careless hands I think it could potentially wreak havoc on a system.