Phyllis - You should head over to the Hardware forum sometime...lot's of people have this scanner and there are several threads!
I have had one since they first came out and Chris got one a few months ago. Barry Fairclough also wrote a review for us
here.
I'll leave this thread in Input/Output since the question is about software settings. How are you hooked up, Firewire or USB? As far as software, my own preference is for the Silverfast Twain over the Epson. It seems to do better with color negatives and slides...and has a pretty good interface.
Oh...I absolutely love this scanner!!
edit: I changed the thread title just a bit to help future searches