My sister-in-law recently lost her sister and I wanted to do a keepsake portrait for her. The only image I had of her sister was a low resolution (121KB) digital and her eyes were closed. I began my work in Photoshop by doing the normal retouch steps. I added the eyes from a picture of another sister and matched them to the face by resizing and changing the perspective. I added a new background, saved the file in PSD format and moved to Painter. There I primarily painted with the Smeary Round Oil brush and the Just Add Water brush. Back to Photoshop for color adjustment and sharpening. I printed an 8 x 10 and it was a bit grainy but when viewed from a distance of 3 feet it looks just fine.
My sister-in-law was very pleased with the results.