Here's my 2 cents...
I have Painter, but I've never had any fine art training. I'm not familiar with the various art media (okay, I know chalk, pen & ink etc., but as for oils, etc. I haven't a clue as to how to apply, blend or manipulate them). The whole "camel hair", impasto stuff is foreign to me.
I can achieve some things in Painter using various clone tools, but as for pure stroking with brushes, I'm all thumbs and usually end up with a smeary mess. Perhaps if I had more time to dedicate to learning Painter, I could accomplish more with better results.
I pull up Painter about once every 3 or 4 months and try, try again, but have yet to master any one technique. I envy those who have a background in art and have a better understanding of how the various media "works"